The estuary of River Tagus, with an extension of 50Km and between 2 and 14Km in width, offers the Port of Lisbon excellent navigating conditions. The main access channel of the port has depths of -15,5m ZH.

River traffic permits the transport of goods between the two margins of the estuary as well as along a significant part of the River Tagus itself.

The port of Lisbon is integrated in the railway network of the region of Lisbon which is articulated with the national and transeuropean transport networks.

On the North bank of River Tagus, the Port has an internal road system which is organised around a main longitudinal axle in which various own routes converge and which serve the different terminals and others which establishes a connection to the external network. The same longitudinal route is also intercepted by the railway branch which services the port. The south bank in served by various fast routes which facilitate the access of goods to national and international transport networks.

The main railway accesses which serve the Port of Lisbon are the Northern Line (Lisbon-Oporto) on the North bank of River Tagus, and the Southern and South-eastern Line (Barreiro-Faro) on the South bank to access the Algarve.

Access to the port from remaining countries of the European Continent is established via the Northern Line which is joined to the Minho Line (Oporto-Valença) to reach the Northwest of Spain; the Beira Alta Line (Pampilhosa-Vilar Formoso) to reach the Centre and North of Spain, as well as the rest of Europe; and the branch of Cáceres (Entroncamento-Portalegre-Cáceres) with a direct connection to the Spanish border and Madrid.

From the internal port park which exists on the Northern bank of the Tagus, various fact routes divert traffic from the urban traffic: the Eixo Norte-Sul, CRIL, CREL, Segunda Circular, IP7 and IC32. The Port of Lisbon is equally connected with the Main Itinerary roads - IP1 (Access to the North and South of the Country), A1 (access to the North), A2 (access to the South of the Country), A5 (Cascais corridor) and the A8 (access to the West area) – which then articulate with the international connections via the A3, IP4 and IP5 (access to the North) the A6 (direct access Madrid) and the IC1 (access to the South).

On the South bank, goods flow through various fast routes which bring the main terminals closer to the main national highways: the A1 to drain the load towards the North, the A2 which serves the South of the country and also the A6 which reaches the Spanish border.